More than two decades ago, scientists discovered that human blood platelet concentrates might be useful as antiinflammatories. In order to better understand the advantages of employing human blood protein as a source of growth factor that assists in angiogenesis and tissue ingrowth, this model was created in consideration of the multiple platelet concentrates such as PRP, PRF, and their various variants. For all its early success, PRP has had a slew of problems that have kept it from reaching its full potential. The method of collecting and processing the human blood was time consuming and therefore an additional anticoagulant such as calcium chloride or bovine thrombin to prevent blood from clotting was mandatory. To overcome these constraints, fresh methods of tissue regeneration have to be developed such as plasma rich fibrin and its variants, one of which is known as advanced-platelet rich fibrin (A-PRF). First and second-generation platelet concentrates as well as the recently introduced A-PRF are discussed in this article

Platelet concentrates, Platelet Rich Plasma, Platelet Rich Fibrin, Advanced Platelet Rich Fibrin, Blood Derivatives, Growth Factors”