Research Article | Open Access
An in vitro study on the assessment of xanthine oxidase inhibitory potential of Coriandrum sativum extract
Priyan.I, V. Vishnu Priya, Kavitha.S, Gayathri.R, Selvaraj.J
Pages: 66-74
Abstract
Introduction:
Coriandrum sativum is a member of the Apiaceae family, is among most widely used medicinal plants, possessing
nutritional as well as medicinal properties.Coriandrum sativum is a summer annual plant commonly used as fresh
green herb, spice, or for its essential oil.Gout is a disease associated with deposits of uric acid in kidney It can be
extremely painful and incapacitating but is extremely treatable in almost all patients. The xanthine oxidase inhibitors
are used to decrease the serum urate levels in patients with gout.The goal of this research is to see if Coriander
sativum extract has anti-gout properties.
Materials and methods: Ethanolic extract was prepared. The phytochemical screening antioxidant and xanthine
oxidase inhibitory activity was studied using the plant extract. The data were analyzed statistically by one-way
analysis of variance (ANOVA) followed by Duncans’s multiple range test, to see the statistical significance among
the groups. The results with the p<0.05 level were considered statistically significant.
Results: Phytochemical screening showed that the extract is rich in carbohydrates, steroids, saponins, terpenoids,
alkaloids, flavonoid and proteins. DPPH radical scavenging activity showed the potent in vitro antioxidant activity
of the plant extract. The extract also possessed a dose dependent increase in the xanthine oxidase inhibitory
potential. Xanthine oxidase inhibitory of the extract might have revealed the antigout activity of plant.
Conclusion: The study reveals that antigout and antioxidant activity of Coriandrum sativum. The presence of
phytochemicals in the extract might be the underlying reason for the beneficial activity of the plant
Keywords
Xanthine oxidase, Coriandrum sativum, antioxidant, phytochemical, gout,innovative technology; novel method.