Background: Hepatitis C virus (HCV) may be a blood-borne virus. It a serious global public health problem and may cause both acute and chronic hepatitis. HCV infection is that the world’s commonest severe disease. the most recent estimates of disease burden show an increase in seroprevalence over the last 15 years to 2.8%, equating to >185 million infections worldwide. Methods: The population of this study comprised the people within the age range of 20-70 years from Puducherry. The study population consists of 125 cases and 102 HCV patients and 23 controls residing within the same region. Among people were selected and invited to complete the questionnaire and perform the tests. Blood samples collected during this study were analyzed to detect the presence of antibodies against HCV using enzyme immunoassay (ELISA) Kit. This study was done to demonstrate some biochemical changes in chronic hepatitis c viral (HCV) infection in State of Puducherry, India. Data was analyzed using the SPSS version 20.0 software. Results: This investigation aims to assess the status of biological changes and risk factors of chronic hepatitis C virus infections. The parameters like S. Bilirubin, ALT (Alanine aminotransferase), AST (Aspartate aminotransferase), ALP (Alkaline Phosphatase), S.Total protein, S.Albumin and S. Globulin contents of HCV samples were estimated. Conclusion: Chronic HCV infection induces abnormal serum aminotransferases (ALT and AST) and no significant effect on ALP and TSB. The predominance of HCV infection increases among the risk factors was found. There’s no significant of risk factors related to control and HCV patients were compared. HCV infection is one among many challenges which must be met within the process of providing quality medical care to disease patients.

Viral hepatitis; Chronic Hepatitis-C Virus; Risk factors, Biochemical Parameters.