Introduction: Chronic Kidney Disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with abnormal kidney function and a progressive decline in Glomerular Filtration Rate (GFR). Because of limitations of creatinine as a biomarker of GFR, new alternative biomarkers are being investigated, such as low molecular weight proteins. Aim: To estimate the levels of Serum Beta-Trace Protein in patients with CKD and to compare them with normal subjects. Methodology: It is a case control study conducted for a period of one year. A total of 100 subjects were selected. (50 cases with CKD and 50 age and gender matched healthy individuals). Student’s t-test was employed for statistical analysis. Results: Beta-Trace Protein concentrations were found to be significantly increased in patients with CKD (mean 52.24 ± 29.6) when compared to control (mean 33.86 ± 12.1). Serum BTP increases as renal function declines and inversely correlated with Creatinine clearance (r = - 0.765). Serum creatinine and blood urea were progressively increased in cases than controls and shows positive correlation with BTP (r = 0.630 and r = 0.721) respectively. Conclusions: Serum BTP levels are significantly increased in patients with CKD. Serum BTP is more precise and accurate marker than serum creatinine in detecting renal dysfunction.

Beta-Trace Protein, Glomerular filtration rate, Chronic kidney disease