CHARACTERIZATION OF THE DERMAL TARGETING OF OPTIMIZED COMBINATORIAL LIPID-NANOSYSTEM
Abstract
Dermal and transdermal medication delivery systems have benefited greatly from the development of nanotechnology and nanomedicine. This research looks at where we are now with (trans)dermal drug delivery using lipid-based nanotechnology and nanomedicine. In this article, we examine and contrast several types of (phospho)lipid-based drug delivery nanosystems, focusing on their capacity to provide regulated drug release to the skin and skin appendages, as well as drug targeting and safety. For both SLN and NLC, measurements and records were kept of the particles' sizes, polydispersity indices, entrapment efficiencies, X-ray powder diffraction patterns, thermal behaviors, and surface morphologies. For topical administration, hydrogels containing SLN and NLC loaded with LID were developed. The skin of guinea pigs was used to test the permeation characteristics of LID SLN gel, LID NLC gel, and a commercially available LID formulation (Xylocaine® gel) in a laboratory setting.