Background: A plenty of colorectal cancer (CRS) screening options really do exist. Screening tests for CRC can change and get altered with regard to the degree of supporting evidence. The main aspects of the questionnaire, (Colonoscopy Satisfaction, and Safety), administered in this research are mainly based on patients’ experience (CSSQP). Aim of the study: The goal of this research is studying the compliance of the blood relatives whose patients are suffering from colorectal cancer to colorectal cancer screening. Subject and Methods: 134 participants of blood relatives of CRC patients undergoing colonoscopy got involved in this cross-sectional study. Those patients were also following primary care or secondary care referrals. The number of participants was calculated after excluding those who rebuffed to be a part of the study as well as the subjects that are already having or had cancer elsewhere. This work was conducted in the Internal Medicine Department, Zagazig University Hospitals. All the participants in this research who were the first-degree relatives of colorectal cancer patients were asked to fill out a questionnaire including providing not only pieces of information about name, age, residence, but also about history of smoking, history of colonoscopy, history of colon cancer in the family, preferred type of screening, and advice to other people as well. Results: The age of the studied cases in this research ranged from 19 to 66 years, with a mean of 44.08 years. Regarding the sex distribution, only53% were males. Most of the participants were married (84.3%) and more than half of them were educated with a percentage of about (57.2%). Most of the participants were having professional occupations with a percentage of about 29.1%, as 60.4% of them were having enough income, and 47.8% were smokers. The study group had no history of other malignancy or previous colonoscopy. Actually, all the studied patients refused colonoscopy for screening, but 91% of them accepted CRC genetic tests; they all accepted any other tests like stool analysis or computed tomography scan of the colon. Regarding advising others to do a colonoscopy, 66.4% reported cases with symptoms to do a colonoscopy, but not for asymptomatic ones. Finally, 82.8% of the studied group preferred medical treatment if they had symptoms. There was a statistically significant increase in the frequency of acceptance of CRC genetic tests among educated compared to noneducated and those who had enough income compared to those who did not have enough income. Conclusion: All of the participants rebuffed to undergo colonoscopy as a screening tool for colorectal cancer, but some preferred non-invasive screening methods, e.g., genetic testing, stool analysis, and computed tomography. Furthermore, they preferred these tests to each other, particularly in symptomatic persons. Shortly speaking, we really do require other easy, non-invasive, acceptable methods for screening. We also need much effort for having the general population persuaded, especially those at risk, to adhere to the screening guidelines

compliance, blood relatives, colorectal cancer (CRC), Colorectal Screening Guidelines.