While its half-life in the circulation is rather brief, the antimalarial medication artemether (ATM) is quite effective. In addition to being related with pro-arrhythmogenic hazards, ATM is also cardiotoxic. Our goal was to create a delivery mechanism that would allow for a sustained release of ATM into the circulation with little cardiotoxicity. Two anti-malarial medicines, artemisinin-based combination therapy (ART) and lumefantrine (LUM), have had their stability assays developed and confirmed using high performance thin layer chromatography (HPTLC). The PCL-NCs had the slowest release rate and the greatest proportion of ATM loading. Atomic force microscopy revealed nanoscale, spherical particles with a narrow size distribution. We used PCL NCs containing ATM for intravenous injection in biological tests.

HPTLC, Artemether, Lumefantrine, Nanoliposome, cardiotoxicity; artemether; malaria; self-assembled polymers;