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Research Article | Open Access
Volume 12 2020 | None
DEVELOPMENT AND OPTIMIZATION OF SUITABLE METHOD OF PREPARATION FOR A STABLE DUAL DRUG LOADED NLC OF 5-FU AND RSV FOR THE TREATMENT OF SKIN CANCER VIA DERMAL DELIVERY
ARCHANA DHYANI
Pages: 795-804
Abstract
Hot melt encapsulation was used to load SLNs with 5-FU, and a gelling agent was then used to transform the SLNs into a gel (Carbopol 940). Particle size ranged from 76.821.48 to 3274.46 nm for the 5-FU-loaded SLNs, while zeta potential was between -11.32.11 and -28.42.40 mV and entrapment effectiveness (%) was between 63.461.13 and 76.082.42. The incorporation of 5-FU into nanoparticles was confirmed by powdered X-ray diffraction analysis. The quick initial release was followed by a persistent release over 48 hours in an in vitro release investigation of 5-FU-loaded SLNs. After 48 hours, the cytotoxic impact of 5-FU-loaded SLNs on cutaneous melanoma and squamous cell carcinoma was larger than that of free 5-FU medication solution.
Keywords
Resveratrol; 5-FU-loaded SLNs ; drug delivery systems; lipid nanoparticles
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