Objectives:Evaluation of orthodontic tooth movement (OTM) with diode laser and level of IL-6 in gingival crevicular fluid (GCF). Materials and Method:Present study consisted of 20 patients who were exposed to diode laser atbaseline, day 15, 30, and 60 during the canine retraction phase. The amount of tooth movement and level of IL- 6 was evaluated and compared at various tooth movement stages. Results: Canine retraction phase in stage 0 in group I was 2.12± 0.11, in group II was 2.14± 0.13, at stage 1 in group I was 2.24± 0.15 and in group II was 2.20± 0.11, at stage 2 was 1.54± 0.28 in group I and 1.62± 0.13 in group II, at stage 3 was 1.46± 0.21 in group I and 1.46± 0.14 in group II. The difference between both groups was nonsignificant (P> 0.05).Mean± SD IL- 6 level (pg/mL) in stage 0 in group I was 0.05± 0.02, in group II was 0.06± 0.02, at stage 1 in group I was 0.21± 0.16 and in group II was 0.13± 0.45, at stage 2 was 0.5± 0.28 in group I and 0.5± 0.36 in group II, at stage 3 was 0.78± 0.42 in group I and 0.49± 0.27 in group II. The dissimilarity among both groups was non- significant (P> 0.05). Conclusion: It was concluded that diode laser found to enhance the orthodontic tooth movement. The level of IL- 6 was higher in laser side as in comparision to control

Canine retraction, interleukin 6, Orthodontic, tooth movement