Introduction:Patients with type 2 diabetes are more likely to have cardiovascular disease (DMT2). This research was created to look into the impact of probiotics and cinnamon on lipid profiles and inflammatory markers in type 2 diabetes patients. Probiotics and cinnamon have been shown to reduce inflammation and modulate the lipid profile. Methods: 120 DMT2 patients who were referred to the diabetic clinic in Karaj were randomly allocated to one of four groups in this crossover, double-blind, randomized clinical experiment. For three months, patients in groups 1 and 2 got one probiotic and one cinnamon capsule each, whereas those in groups 3 and 4 received one probiotic and one rice powder (placebo) capsule. At the conclusion of the intervention, lipid profile and inflammatory indicators were assessed.For statistical analysis, SPSS software used one-way variance and Tukey Analysis. Results:Tumor necrosis factor alpha (TNF), C- reactive protein (CRP), probiotic, and synbiotic levels in the Cholesterol group are significantly lower than those in the control group (p< 0/05). Cinnamon, probiotics, and synbiotics have significantly increased in High Density Lipoprotein (HDL). LDL levels in the probiotic and cinnamon groups had significantly decreased (p< 0/05). Conclusion: The consumption of synbiotic enhanced thelipid profile and some inflammatory biomarkers in patients with DMT2.

DMT2, Lactobacillus, Cinnamon, Inflammatory factor, Lipid profile