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Research Article | Open Access
Volume 12 2020 | None
FORMULATE, OPTIMIZE AND CHARACTERIZE LACTOFERRIN CONJUGATED TEMOZOLOMIDE AND RESVERATROL CO-LOADED NLC FOR THE TREATMENT OF GLIOBLASTOMA
NIDHI DOBHAL
Pages: 739-746
Abstract
The tumor's location, its heterogeneity, and the existence of the blood-brain barrier (BBB) are all factors to consider, and other factors all contribute to the difficulty of treating GBM, and tumor recurrence is common even after treatment with surgery and chemotherapy. For the treatment of GBM, researchers here combined temozolomide and vincristine with nanostructured lipid carriers containing lactoferrin and arginine-glycine-aspartic acid dualligands. The primary difficulties in treating GBM are discussed, as is the crucial role that SLNs and NLCs play as drug carriers in GBM therapy, and the full range of modification techniques that try to alter the SLN and NLC composition for the betterment of treatment results.
Keywords
Gliomatosis, cerebri, nanostructured, lipid, carriers, lactoferrin, temozolomide
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