Research Article | Open Access
Influence of the maternal vaginal, gut, and placental microbiome on pregnancy outcomes – An observational study
Dr. G. Radha Rani, Dr. B. Lalitha Devi
Pages: 897-901
Abstract
Introduction: The human microbiome, encompassing various microbial communities residing within and on the human body, has emerged as a critical determinant of health and disease. During pregnancy, the maternal microbiome undergoes dynamic shifts, particularly in the vaginal, gut, and placental regions, which play essential roles in maternal-fetal health. Understanding the intricate interplay between these microbial communities and pregnancy outcomes is of paramount importance for improving prenatal care and maternal health.
Methods: Samples were collected from pregnant women at various gestational ages during routine prenatal visits. Vaginal, gut, and placental samples were collected, and DNA extraction and sequencing were performed to analyze microbial composition. Clinical data including demographic information and pregnancy outcomes were collected from electronic medical records. Statistical analysis was conducted to assess associations between microbial composition and pregnancy outcomes.
Results: Demographic characteristics of the study participants are presented, showing a diverse population in terms of age and education level. Microbial composition analysis revealed distinct profiles in the maternal vaginal, gut, and placental microbiomes. Associations were observed between specific microbial compositions and pregnancy outcomes, including preterm birth, gestational diabetes, and preeclampsia.
Discussion: Our findings highlight the significance of the maternal microbiome in shaping pregnancy outcomes. Associations between microbial dysbiosis and adverse pregnancy outcomes underscore the potential for microbiome-targeted interventions in prenatal care. Comparison with previous studies further supports the importance of considering the maternal microbiome in understanding pregnancy complications.
Conclusion: This study contributes to our understanding of the complex interactions between the maternal microbiome and pregnancy outcomes. By elucidating the role of microbial composition in maternal-fetal health, we pave the way for personalized interventions to optimize pregnancy care and improve maternal and neonatal health outcomes.
Keywords
The human microbiome, encompassing various microbial communities residing within and on the human body, has emerged as a critical determinant of health and disease.