Research Article | Open Access
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND INVITRO EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY OF Fragaria ananassa ( strawberry ) EXTRACT
Sujitha S, V. Vishnu Priya, Gayathri.R, Kavitha.S
Pages: 101-107
Abstract
Introduction : Xanthine oxidase is a superoxide producing enzyme which synthesis uric acid from hypoxanthine.
Gout is an inflammatory disease which targets the joints and is caused by an abnormal buildup of uric acid in the
blood. Allopurinol is a well known xanthine oxidase inhibitor and widely used in the therapeutic and clinical
management of gout and used as a first line treatment for hyperuricemia and gout. Fragaria ananassa is a well known
antioxidant and rich in Vitamin C.
Aim : The aim of this study is to analyse phytochemical constituents and evaluate xanthine oxidase inhibitory
activity of Fragaria ananassa (strawberry) extract.
Methods : The extract was tested for its phytochemical constituents and analysed for its anti gout potential by
estimating the xanthine oxidase inhibitory potential.
Results : The results of qualitative phytochemical analysis of strawberry extract are given in table 1. The results
revealed the presence of Terpenoids, Flavonoids, Carbohydrates and Steroids in strawberry extract.The extract also
showed a significant presence of anti gout potential.
Conclusion : Aqueous extract of strawberry exhibits xanthine oxidase inhibitory activity. Further in vitro studies
and detailed molecular mechanisms may be required for developing these extracts into commercially available drugs
for treatment.
Keywords
Novel method, Xanthine oxidase; strawberry extract; Phytochemical analysis; Gout; Hyperuricemia; Antioxidant, Innovative technique