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Research Article | Open Access
Volume 12 2020 | None
PREPARE AND EVALUATE DRUG LOADED POLYMERIC NANO-FIBRES FOR THE TREATMENT OF BRAIN TUMOR
Dr Prashant Gahtori
Pages: 729-738
Abstract
Due to poor diagnosis and profiling, brain tumors, particularly glioblastoma, continue to be the most aggressive type of all malignancies. The most difficult aspect of treating brain cancer is getting chemotherapeutic medicines and other anti-cancer substances across the blood-brain barrier and into the tumor cells where they can do the best. The strong, highly-tunable carrier systems known as polymeric nanoparticles (NPs) may be able to get around those challenges. Several studies have shown that properly built polymeric NPs may specifically target cancer cells in the central nervous system, enhance medication bioavailability, and decrease systemic toxicity by crossing the blood-brain barrier. While there are currently no clinical trials including the use of polymeric NPs for the treatment of brain cancer, there is growing preclinical evidence that they may be effective. This overview looks at several polymeric NPs and how their composition, surface changes, and administration mechanism affect their efficacy in treating brain tumors.
Keywords
Nanomaterials, nanoparticles; liposomes; blood–brain barrier; drug delivery;
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