The prevalence of diabetes worldwide has extended epidemic magnitudes and is expected to affect more than 350 million people by the year 2035.Diabetic Nephropathy (DN) is the most prevalent chronic kidney disease and is the major cause of End-Stage Renal Disease (ESRD) worldwide. This is predominantly due to the growing incidence of type 2 diabetes assocaited with obesity.Albuminuria has several confounding issues associated with it such as exercise, urinary tract infection, acute illness and cardiac failure. Furthermore,it has been reported to occur in the urine of non-diabetic subjects, indicating the non-specificty of albuminuria for accurate prediction of diabetic kidneydisorder.Nephrin is a 180 KD transmembrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type.Nephrin biomarker can be used as predictoir for early diagnosis of nephropathy in diabetics

Nephrin, Diabetic Nephropathy