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Research Article | Open Access
Volume 14 2022 | None
TARGETED PROTEIN DEGRADATION BY SMALL MOLECULES: Applications in Biology and Medicine
ANUPRIYA ADHIKARI
Pages: 2914-2920
Abstract
Targeted Protein Degradation by Small Molecules is a promising approach for developing new therapeutics that can selectively eliminate disease-causing proteins. This approach uses small molecules to redirect the cell's natural protein degradation machinery towards specific target proteins, which are marked for degradation by the small molecule. This has the potential to be a highly effective way to eliminate disease-causing proteins, as it allows for precise control over protein levels and can overcome some of the limitations of traditional small molecule inhibitors, such as off-target effects. Targeted Protein Degradation by Small Molecules is a rapidly evolving field with significant potential for the development of new therapeutics for a range of diseases, including cancer, neurodegenerative disorders, and viral infections. However, there are still many challenges to overcome, such as improving the selectivity and potency of small molecule degraders, understanding the mechanisms of action and potential side effects, and developing methods for delivery of these molecules to the relevant cells and tissues.
Keywords
Targeted Protein Degradation by Small Molecules is a promising approach for developing new therapeutics that can selectively eliminate disease-causing proteins.
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